ea0067o30 | Oral Presentations | EYES2019
Nikolaou Nikolaos
, Gathercole Laura L
, Marchand Lea
, Althari Sara
, Dempster Niall J
, Green Charlotte J
, van de Bunt Martijn
, McNeil Catriona
, Arvaniti Anastasia
, Hughes Beverly A
, Sgromo Bruno
, Gillies Richard S
, Ryan John
, Arlt Wiebke
, Hodson Leanne
, Tomlinson Jeremy W
Objective: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Steroid hormones and bile acids are potent regulators of hepatic carbohydrate and lipid metabolism. Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis.Methods: Human liver biopsies were obtained from 34 obese patients and AKR1D1 mRNA expres...